GABRA1 抗体 (pSer327)
Quick Overview for GABRA1 抗体 (pSer327) (ABIN5688897)
抗原
See all GABRA1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer327
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特异性
- Specific for ~45k GABAA receptor γ2 subunit phosphorylated at Ser327. Immunolabeling of the GABAA band is completely blocked by λ-phosphatase treatment.
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纯化方法
- Affinity Purified
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免疫原
- Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser327 of the GABAA receptor, y2 subunit.
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anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1) (AA 15-34) antibody
GABRA1 适用: 大鼠 WB, ICC, IF, AA 宿主: 小鼠 Monoclonal N151-3 (Formerly S151-3) unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1) (AA 350-385) antibodyGABRA1 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S399-19 unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1) (AA 15-34) antibody (HRP)GABRA1 适用: 大鼠 WB, ICC, IF, AA 宿主: 小鼠 Monoclonal N151-3 (Formerly S151-3) HRP
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1) (AA 350-385) antibody (HRP)GABRA1 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S399-19 HRP
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1) (AA 15-34) antibody (FITC)GABRA1 适用: 大鼠 WB, ICC, IF, AA 宿主: 小鼠 Monoclonal N151-3 (Formerly S151-3) FITC
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1) (AA 350-385) antibody (FITC)GABRA1 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S399-19 FITC
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1) (AA 15-34) antibody (Biotin)GABRA1 适用: 大鼠 WB, ICC, IF, AA 宿主: 小鼠 Monoclonal N151-3 (Formerly S151-3) Biotin
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1) (AA 350-385) antibody (Biotin)GABRA1 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S399-19 Biotin
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1) (AA 15-34) antibody (PE)GABRA1 适用: 大鼠 WB, ICC, IF, AA 宿主: 小鼠 Monoclonal N151-3 (Formerly S151-3) PE
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1) (AA 350-385) antibody (PE)GABRA1 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S399-19 PE
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 100 μLin 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg per mL BSA and 50 % glycerol.
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储存条件
- -20 °C
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储存方法
- GABAA Receptor (Ser327) antibody can be stored at -20°C and is stable at -20°C for at least 1 year.
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- GABRA1 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1))
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别名
- GABAA Receptor
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背景
- Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gamma,s, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990, Whiting et al., 1999, Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. It has recently been suggested that PKC? regulates the sensitivity of GABAA alpha1beta2gamma2 receptors to ethanol and benzodiazepines through phosphorylation of serine 327 in the large intracellular loop of gamma2 (Qi et al., 2007)
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分子量
- 45 kDa
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基因ID
- 29709
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UniProt
- P18508
抗原
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