AQP2 抗体 (pSer261)
Quick Overview for AQP2 抗体 (pSer261) (ABIN5688893)
抗原
See all AQP2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer261
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纯化方法
- Affinity Purified
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免疫原
- Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser261 of rat aquaporin 2.
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应用备注
- The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will react with canine, bovine, chicken, human, mouse and non-human primate tissues based on the fact that these species have 100 % homology with the amino acid sequence used as antigen.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 100 μLin 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg per mL BSA and 50 % glycerol.
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储存条件
- -20 °C
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储存方法
- Aquaporin 2 antibody can be stored at -20°C and is stable at -20°C for at least 1 year.
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: "Immunohistochemical Expression of AQP2 and HSP70 in Broiler Kidney Tissue Treated with Salix tetrasperma Roxb. Extract under Heat Exposure." in: TheScientificWorldJournal, Vol. 2021, pp. 8711286, (2022) (PubMed).
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: "Immunohistochemical Expression of AQP2 and HSP70 in Broiler Kidney Tissue Treated with Salix tetrasperma Roxb. Extract under Heat Exposure." in: TheScientificWorldJournal, Vol. 2021, pp. 8711286, (2022) (PubMed).
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- AQP2 (Aquaporin 2 (Collecting Duct) (AQP2))
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别名
- Aquaporin 2
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背景
- Aquaporin 2 (AQP2) is a hormonally regulated water channel located in the renal collecting duct. Mutations in the AQP2 gene cause hereditary nephrogenic diabetes insipidus in humans (Iolascon et al.,2007). A vasopressin induced cAMP increase results in the phosphorylation of AQP2 at serine-256 and its translocation from the intracellular vesicles to the apical membrane of principal cells (van Balkom et al., 2002). Recently, serine-261 has been identified as a novel phosphorylation site on AQP2 and levels of phosphorylated S261 have been shown to decrease with vasopressin treatment suggesting its involvement in vasopressin-dependent AQP2 trafficking (Hoffert et al., 2007).
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分子量
- 29/37 kDa
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基因ID
- 25386
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UniProt
- P34080
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途径
- Response to Water Deprivation
抗原
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