Glycine Receptor (GRD) (N-Term) 抗体
GRD
适用: 大鼠
WB, IHC
宿主: 兔
Polyclonal
unconjugated
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- 抗原 See all Glycine Receptor (GRD) 抗体
- Glycine Receptor (GRD)
- 抗原表位
- N-Term
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适用
- 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- 非结合性
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 纯化方法
- Affinity Purified
- 免疫原
- Glycine Receptor polyclonal antibody was raised against a peptide derived from the amino terminus of the *1 subunit of Glycine Receptor.
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- Discover our top product GRD Primary Antibody
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anti-Glycine Receptor (GRD) (N-Term) antibody
GRD 适用: 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Glycine Receptor antibody is specific immunolabeling of the ~48k *1 and *2 subunits of the receptor in Western blots of rat spinal cord and in cell extracts containing the recombinant human glycine receptors. Immunolabeling blocked by preadsorption of antibody with the peptide immunogen derived from the amino terminus of the *1 subunit of the receptor. Applications include Dot Blots (DB) and Western Blots (WB). Rabbit anti-Glycine Receptor recognizes glycine receptor α,1 and α,2 in rat spinal cord and brain stem. When internally tested under ideal conditions the working dilutions were 1:1000 for DB and WB.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 储存条件
- -20 °C
- 储存方法
- Glycine Receptor antibody can be stored at -20°C. After reconstitution in 50 μ,l PBS, the antibody should be aliquot and stored at -20°C. This product is stable at -20°C for at least 1 year.
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- 抗原
- Glycine Receptor (GRD)
- 别名
- Glycine Receptor (GRD 产品)
- 别名
- HKPX2 antibody, glycine receptor beta antibody, GLRB antibody
- 背景
- Gamma-amGlycine is an important inhibitory transmitter in the brainstem and spinal cord. Glycine receptors are members of the ligand-gated ion channel family (LGICs) that mediate rapid chemical neurotransmission. The binding of glycine to its receptor produces a large increase in chloride conductance, which causes membrane hyperpolarization. Glycine receptors are anchored at inhibitory chemical synapses by a cytoplasmic protein, gephyrin. Gene targeting in mice showed that gephyrin is required for synaptic clustering of glycine receptors in spinal cord. The glycine receptor has been used to great advantage in the identification of the binding sites for alcohol on the LGIC family of proteins. These receptors have also been extremely useful in studies of synaptic clustering of receptors. During postnatal motoneuron development, the glycine receptor alpha subunit changes from alpha2 (fetal) to alpha1 (adult).
- 分子量
- 48 kDa
- 基因ID
- 25674
- UniProt
- P07727
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