Connexin 抗体 (C-Term)
This anti-Connexin antibody is a 兔 多克隆 antibody detecting Connexin in WB. Suitable for 小鸡, 犬, 人, 小鼠, 大鼠, 绵羊, 非洲爪蟾 和 斑马鱼.
Quick Overview for Connexin 抗体 (C-Term) (ABIN5688865)
抗原
Connexin
适用
小鸡, 犬, 人, 小鼠, 大鼠, 绵羊, 非洲爪蟾, 斑马鱼
宿主
兔
克隆类型
多克隆
应用范围
Western Blotting (WB)
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抗原表位
- C-Term
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纯化方法
- Affinity Purified
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免疫原
- Peptide corresponding to amino acid residues from the C-terminal region of rat connexin43.
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应用备注
- The antibody has been directly tested for reactivity in Western blots in rat tissues. It is anticipated that the antibody will also work with chicken, dog, finch, human, mouse, non-human primate, sheep, Xenopus and zebra fish tissues based on the fact that these species have 100 % homology with the amino acid sequence used as antigen.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 100 μLin 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg per mL BSA and 50 % glycerol.
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储存条件
- -20 °C
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储存方法
- Connexin antibody can be stored at -20°C and is stable at -20°C for at least 1 year.
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- Connexin
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背景
- Gap junctional intercellular communication is thought to play a key role in development and may also be involved in epilepsy (Aronica et al., 2001). Connexin43 forms gap-junctional channels and regulates the permeability of these gap junctions to small organic molecules. Permeability of connexin43 is known to be regulated by phosphorylation at er368 by protein kinase C (Yogo et al., 2002, Bao et al., 2004a). Phosphorylation of Ser368 by PKC induces a conformational change of connexin43 that results in a decrease in gap junction permeability (Bao et al., 2004b).
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分子量
- 43 kDa
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基因ID
- 24392
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UniProt
- P08050
抗原
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