SLC6A1 抗体 (C-Term)
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Quick Overview for SLC6A1 抗体 (C-Term) (ABIN5688853)
抗原
See all SLC6A1 (GAT1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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纯化方法
- Affinity Purified
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免疫原
- Peptide corresponding to amino acid residues from the C-terminal region of rat GAT-1.
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应用备注
- The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will also react with mouse tissue based on the fact that this species has 100 % homology with the amino acid sequence used as antigen.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 100 μLin 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg per mL BSA and 50 % glycerol.
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储存条件
- -20 °C
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储存方法
- GAT-1 antibody can be stored at -20°C and is stable at -20°C for at least 1 year.
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- SLC6A1 (GAT1) (GABA Transporter 1 (GAT1))
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别名
- GAT-1
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背景
- Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABA plasma membrane transporters (GATs) influence synaptic neurotransmission by high-affinity uptake and release of GABA. To date, four distinct GABA transporters have been identified: GAT-1, GAT-2, GAT-3, and BGT-1. GAT-1, the most abundant of the transporters, is found predominantly in neurons, but also in some specialized glia (Minelli et al., 1995). GAT-1 is thought to play a key role in epileptogenesis (Zhao et al. 2003).
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分子量
- 67 kDa
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基因ID
- 79212
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UniProt
- P23978
抗原
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