Ubiquitin hydrolase 1 抗体
The 小鼠 单克隆 anti-Ubiquitin hydrolase 1 antibody is suitable to detect Ubiquitin hydrolase 1 in samples from 人, Cow, 小鼠 和 大鼠. It has been validated for WB 和 IHC.
产品编号 ABIN5688748
发货至:
中国
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Quick Overview for Ubiquitin hydrolase 1 抗体 (ABIN5688748)
抗原
Ubiquitin hydrolase 1
适用
人, Cow, 小鼠, 大鼠
宿主
小鼠
克隆类型
单克隆
标记
非结合性
应用范围
Western Blotting (WB), Immunohistochemistry (IHC)
克隆位点
MCA-BH7
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特异性
- Specific for the ~24 kDa UCHL1 protein.
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纯化方法
- Total IgG fraction
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免疫原
- Recombinant full length human UCHL1 purified from E. coli.
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亚型
- IgG1
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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储存条件
- -20 °C
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储存方法
- Ubiquitin Hydrolase 1 antibody can be stored at -20°C and is stable at -20°C for at least 1 year.
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- Ubiquitin hydrolase 1
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背景
- Ubiquitin C-terminal hydrolase 1 (UCHL1) is also known as ubiquitin carboxyl esterase L1, ubiquitin thiolesterase, neuron-specific protein PGP9.5 and Park5. It was originally identified as a major component of the neuronal cytoplasm from 2-dimensional gel analysis of brain tissues, and was given the name PGP9.5. It was later found that ubiquitin C-terminal hydrolase enzyme activity was associated with the PGP9.5 protein. The ubiquitin C-terminal hydrolases cleave ubiquitin from other molecules. Regulation of the ubiquitin pathway is very important and many disease states are associated with defects in this pathway. Genetic knockout of UCHL1 in mice results in a motor neuron degeneration similar to the spontaneous gracile axonal dystrophy (gad) mutant mice. Point mutations in the UCHL1 gene are associated with some forms of human Parkinson's disease. Since UCHL1 is heavily expressed in neurons, it is released in large amounts following injury or degeneration, so the detection of UCHL1 in CSF and other bodily fluids can be used as a biomarker.
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分子量
- 24 kDa
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基因ID
- 7345
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UniProt
- P09936
抗原
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