CIRBP 抗体 (C-Term)
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Quick Overview for CIRBP 抗体 (C-Term) (ABIN568702)
抗原
See all CIRBP 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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序列
- C-RDSYDSYATH NE
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特异性
- Recognizes CIRBP (aa 161-172).
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交叉反应 (详细)
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Species reactivity (expected):Rat, Canine (Dog), Bovine.
Species reactivity (tested):Human, Mouse. -
纯化方法
- Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
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免疫原
- Peptide with sequence from the C-Terminus of the protein sequence according to NP_001271.1. Genename: CIRBP
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- CIRBP (Cold Inducible RNA Binding Protein (CIRBP))
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别名
- CIRBP
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背景
- CIRBP, also named as A18HNRNP and CIRP, is a cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. CIRBP is also involved in cap-independent translation upon moderate cold-shock. It acts as a translational activator. CIRBP is a suppressive rather stimulatory effect on proliferation. It acts as a translational repressor. CIRBP is an immortalized gene in murine primary cells. CIRBP promotes assembly of stress granules (SGs), when overexpressed. It is a potential proto-oncogenic proteins upon overexpression. Suppression of CIRBP increased the apoptotic cell population of neural stem cells at moderate low temperature.Synonyms: A18HNRNP, CIRP, Cold-inducible RNA-binding protein, Glycine-rich RNA-binding protein CIRP
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基因ID
- 1153
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NCBI登录号
- NP_001271
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UniProt
- Q14011
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途径
- Ribonucleoprotein Complex Subunit Organization
抗原
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