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CD19 抗体

CD19 适用: 人 FACS, IF 宿主: 小鼠 Monoclonal 4G7 unconjugated
产品编号 ABIN567993
发货至: 中国
  • 抗原 See all CD19 抗体
    CD19 (CD19 Molecule (CD19))
    适用
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    宿主
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    小鼠
    克隆类型
    • 243
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    单克隆
    标记
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    This CD19 antibody is un-conjugated
    应用范围
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    Flow Cytometry (FACS), Immunofluorescence (IF)
    特异性
    This antibody recognizes CD19 (B4), a 95 kDa type I transmembrane glycoprotein of immunoglobulin superfamily, expressed on B lymphocytes and follicular dendritic cells, it is lost on plasma cells.
    交叉反应 (详细)
    Species reactivity (tested):Human.
    纯化方法
    Protein-A affinity chromatography
    免疫原
    Human CCL (chronic lymphocytic leukemia) cells
    克隆位点
    4G7
    亚型
    IgG1
    Top Product
    Discover our top product CD19 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    PBS, pH ~7.4 with 15 mM Sodium Azide as preservative
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原
    CD19 (CD19 Molecule (CD19))
    别名
    CD19 (CD19 产品)
    背景
    CD19 is a transmembrane glycoprotein of Ig superfamily expressed by B cells from the time of heavy chain rearrangement until plasma cell differentiation. It forms a tetrameric complex with CD21 (complement receptor type 2), CD81 (TAPA-1) and Leu13. Together with BCR (B cell antigen receptor), this complex signals to decrease B cell treshold for activation by the antigen. Besides being signal-amplifying coreceptor for BCR, CD19 can also signal independently of BCR coligation and it turns out to be a central regulatory component upon which multiple signaling pathways converge. Mutation of the CD19 gene results in hypogammaglobulinemia, whereas CD19 overexpression causes B cell hyperactivity.Synonyms: B-cell marker, B-lymphocyte surface antigen B4, Differentiation antigen CD19, Leu-12
    基因ID
    930
    NCBI登录号
    NP_001761
    UniProt
    P15391
    途径
    Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
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