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TCR alpha/beta 抗体 (APC)

There are 5+ publications for this product available. The 小鼠 单克隆 anti-TCR alpha/beta antibody is suitable to detect TCR alpha/beta in samples from 人. It has been validated for FACS.
产品编号 ABIN567986
发货至: 中国
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Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for TCR alpha/beta 抗体 (APC) (ABIN567986)

抗原

TCR alpha/beta (T Cell Receptor alpha/beta (TCR alpha/beta))

适用

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宿主

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小鼠

克隆类型

  • 54
单克隆

标记

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This TCR alpha/beta antibody is conjugated to APC

应用范围

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Flow Cytometry (FACS)

克隆位点

IP26
  • 交叉反应 (详细)

    Species reactivity (tested):Human.

    纯化方法

    Size-Exclusion Chromatography and adjusted for direct use

    亚型

    IgG1
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 缓冲液

    PBS, 15 mM Sodium Azide, 0.2 % (w/v) high-grade protease free BSA

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    DO NOT FREEZE! This products is photosensitive and should be protected from light.

    储存条件

    4 °C

    储存方法

    Store undiluted at 2-8 °C.
  • Kuttruff, Koch, Kelp, Pawelec, Rammensee, Steinle: "NKp80 defines and stimulates a reactive subset of CD8 T cells." in: Blood, Vol. 113, Issue 2, pp. 358-69, (2009) (PubMed).

    Sullivan, Coscoy: "Downregulation of the T-cell receptor complex and impairment of T-cell activation by human herpesvirus 6 u24 protein." in: Journal of virology, Vol. 82, Issue 2, pp. 602-8, (2008) (PubMed).

    Chentouf, Ghannam, Bès, Troadec, Cérutti, Chardès et al.: "Recombinant anti-CD4 antibody 13B8.2 blocks membrane-proximal events by excluding the Zap70 molecule and downstream targets SLP-76, PLC gamma 1, and Vav-1 from the CD4-segregated Brij 98 ..." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 179, Issue 1, pp. 409-20, (2007) (PubMed).

    Ortonne, Huet, Gaudez, Marie-Cardine, Schiavon, Bagot, Musette, Bensussan: "Significance of circulating T-cell clones in Sezary syndrome." in: Blood, Vol. 107, Issue 10, pp. 4030-8, (2006) (PubMed).

    Edwards, Grzyb, Dressler, Mansel, Zava, Sledge, McGuire: "Monoclonal antibody identification and characterization of a Mr 43,000 membrane glycoprotein associated with human breast cancer." in: Cancer research, Vol. 46, Issue 3, pp. 1306-17, (1986) (PubMed).

  • 抗原

    TCR alpha/beta (T Cell Receptor alpha/beta (TCR alpha/beta))

    别名

    T Cell Receptor / TCR alpha/beta

    背景

    The antigen-specific T cell receptor (TCR) is composed of either alpha and beta subunit, or gamma and delta subunit. Majority of T cells present in the blood, lymph and secondary lymphoid organs express TCR alpha/beta heterodimers, whereas the T cells expressing TCR gamma/delta heterodimers are localized mainly in epithelial tissues and at the sites of infection. The subunits of TCR heterodimers are covalently bonded and in the endoplasmic reticulum they associate with CD3 subunits to form functional TCR-CD3 complex. Lack of expression of any of the chains is sufficient to stop cell surface expression.
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