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KPNA4 抗体 (AA 1-100)

This anti-KPNA4 antibody (ABIN5675543) is a Rabbit Polyclonal antibody detecting KPNA4 in WB, ELISA, IF (p), IF (cc), IHC (p), ICC, IHC (fro). Suitable for Mouse.
产品编号 ABIN5675543
发货至: 中国

Quick Overview for KPNA4 抗体 (AA 1-100) (ABIN5675543)

抗原

See all KPNA4 抗体
KPNA4 (Karyopherin (Importin) alpha 4 (KPNA4))

适用

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小鼠

宿主

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克隆类型

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多克隆

标记

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This KPNA4 antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • 抗原表位

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    AA 1-100

    交叉反应

    小鼠

    预测反应

    Human,Rat,Cow,Horse,Chicken

    纯化方法

    Purified by Protein A.

    免疫原

    KLH conjugated synthetic peptide derived from human KPNA4

    亚型

    IgG
  • 应用备注

    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

    有效期

    12 months
  • 抗原

    KPNA4 (Karyopherin (Importin) alpha 4 (KPNA4))

    别名

    KPNA4

    背景

    Synonyms: Importin subunit alpha-3, KPNA4, Importin alpha Q1, Qip1, Karyopherin subunit alpha-4, QIP1

    Background: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a nonclassical NLS.

    基因ID

    3840

    UniProt

    O00629

    途径

    Protein targeting to Nucleus
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