PUF60 抗体 (AA 1-100) (Biotin)
Quick Overview for PUF60 抗体 (AA 1-100) (Biotin) (ABIN5675527)
抗原
See all PUF60 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-100
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human PUF60
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亚型
- IgG
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anti-Poly-U Binding Splicing Factor 60KDa (PUF60) (C-Term) antibody
PUF60 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, 豚鼠, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Poly-U Binding Splicing Factor 60KDa (PUF60) (C-Term) antibodyVerified PUF60 适用: 人 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Poly-U Binding Splicing Factor 60KDa (PUF60) (AA 243-542) antibodyPUF60 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Poly-U Binding Splicing Factor 60KDa (PUF60) antibodyPUF60 适用: 人 WB, IHC (p), IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Poly-U Binding Splicing Factor 60KDa (PUF60) (AA 1-516) antibodyPUF60 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1C1 unconjugated
anti-Poly-U Binding Splicing Factor 60KDa (PUF60) (C-Term) antibodyPUF60 适用: 人 WB, IHC (p), IF, ICC, IHC (wm) 宿主: 兔 Polyclonal unconjugated
anti-Poly-U Binding Splicing Factor 60KDa (PUF60) (C-Term) antibodyPUF60 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Poly-U Binding Splicing Factor 60KDa (PUF60) (C-Term) antibodyPUF60 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, 豚鼠, 斑马鱼, 小鸡, 非洲爪蟾, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Poly-U Binding Splicing Factor 60KDa (PUF60) (AA 371-420) antibodyPUF60 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, 豚鼠, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Poly-U Binding Splicing Factor 60KDa (PUF60) (AA 1-100) antibodyPUF60 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C for 12 months.
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有效期
- 12 months
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- PUF60 (Poly-U Binding Splicing Factor 60KDa (PUF60))
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别名
- PUF60
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背景
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Synonyms: 60 kDa poly(U)-binding-splicing factor, FBP-interacting repressor, FIR, FLJ31379, FUSE-binding protein-interacting repressor, Poly U binding splicing factor 60KDa, Poly(U)-binding-splicing factor PUF60, poly-U binding splicing factor PUF60, PUF60, PUF60_HUMAN, pyrimidine tract binding splicing factor, Ro ribonucleoprotein-binding protein 1, Ro-binding protein 1, RoBP1, RoBPI, siah binding protein 1, Siah-binding protein 1, Siah-BP1, SIAHBP1
Background: DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Isoform 6 failed to repress MYC transcription and inhibited FIR-induced apoptosis in colorectal cancer. Isoform 6 may contribute to tumor progression by enabling increased MYC expression and greater resistance to apoptosis in tumors than in normal cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA, binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with TROVE2. Binds to poly(U) RNA.
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基因ID
- 22627
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UniProt
- Q9UHX1
抗原
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