TEN1 抗体 (N-Term)
This anti-TEN1 antibody is a 兔 多克隆 antibody detecting TEN1 in WB. Suitable for 小鼠.
Quick Overview for TEN1 抗体 (N-Term) (ABIN5673933)
抗原
TEN1
(TEN1 Telomerase Capping Complex Subunit (TEN1))
适用
小鼠
宿主
兔
克隆类型
多克隆
应用范围
Western Blotting (WB)
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抗原表位
- N-Term
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序列
- GSTLRTFGRL YLYDMARSLM TLAAPQKPDQ CQLLVCTNLV EPFEAHVNFL
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纯化方法
- Affinity purified
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免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of Mouse TEN1
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- TEN1 (TEN1 Telomerase Capping Complex Subunit (TEN1))
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别名
- TEN1
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背景
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Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis, it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha. The CST complex facilitates recovery from many forms of exogenous DNA damage, seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins (By similarity).
Alias Symbols: 2310004N24Rik
Protein Size: 161 -
基因ID
- 69535
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NCBI登录号
- NM_027107, NP_081383
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UniProt
- Q9D7K2
抗原
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