NGEF 抗体 (C-Term)
Quick Overview for NGEF 抗体 (C-Term) (ABIN5673216)
抗原
See all NGEF 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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序列
- GWFPSSMTEE ILNPKIRSQN LKECFRVHKM EDPQRSQNKD RRKLGSRNRQ
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纯化方法
- Affinity purified
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免疫原
- The immunogen is a synthetic peptide directed towards the C terminal region of mouse NGEF
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anti-Neuronal Guanine Nucleotide Exchange Factor (NGEF) (AA 612-710) antibody
NGEF 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 6E7 unconjugated
anti-Neuronal Guanine Nucleotide Exchange Factor (NGEF) (AA 429-710) antibodyNGEF 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Neuronal Guanine Nucleotide Exchange Factor (NGEF) (AA 495-710) antibodyNGEF 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Neuronal Guanine Nucleotide Exchange Factor (NGEF) (AA 187-220), (N-Term) antibodyNGEF 适用: 人, 大鼠 WB 宿主: 兔 Polyclonal RB53236 unconjugated
anti-Neuronal Guanine Nucleotide Exchange Factor (NGEF) (AA 669-704), (C-Term) antibodyNGEF 适用: 人 WB 宿主: 兔 Polyclonal RB53235 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- NGEF (Neuronal Guanine Nucleotide Exchange Factor (NGEF))
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别名
- NGEF
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背景
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Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension.
Alias Symbols: Tims2, ephexin
Protein Size: 620 -
基因ID
- 53972
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NCBI登录号
- NM_001111314, NP_001104784
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途径
- Neurotrophin Signaling Pathway
抗原
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