FIP1L1 抗体 (N-Term)
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北京 101111
Quick Overview for FIP1L1 抗体 (N-Term) (ABIN5673070)
抗原
See all FIP1L1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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序列
- GIEDETAENG VPKPKVTETE DDSDSDSDDD EDDVHVTIGD IKTGAPQYGS
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纯化方法
- Affinity purified
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免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of Human FIP1L1
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anti-FIP1 Like 1 (FIP1L1) (AA 1-300) antibody
FIP1L1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-FIP1 Like 1 (FIP1L1) antibodyFIP1L1 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-FIP1 Like 1 (FIP1L1) (AA 1-378) antibodyFIP1L1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2H4 unconjugated
anti-FIP1 Like 1 (FIP1L1) antibodyFIP1L1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-FIP1 Like 1 (FIP1L1) (AA 509-558) antibodyFIP1L1 适用: 人, 小鼠, 大鼠, Cow, 马, 犬, Pig, 豚鼠, 斑马鱼, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-FIP1 Like 1 (FIP1L1) antibodyFIP1L1 适用: 人, 小鼠, 大鼠, 犬 WB 宿主: 兔 Polyclonal unconjugated
anti-FIP1 Like 1 (FIP1L1) (C-Term) antibodyFIP1L1 适用: 人, 小鼠, 大鼠, Cow, 马, 犬, 豚鼠, 斑马鱼, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- FIP1L1 (FIP1 Like 1 (FIP1L1))
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别名
- FIP1L1
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背景
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This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Alias Symbols: Rhe, FIP1, hFip1
Protein Size: 594 -
基因ID
- 81608
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NCBI登录号
- NM_001134937, NP_001128409
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UniProt
- Q6UN15
抗原
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