SMC6 抗体 (N-Term)
The 兔 多克隆 anti-SMC6 antibody is suitable to detect SMC6 in samples from 人. It has been validated for WB.
产品编号 ABIN5672641
发货至:
中国
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Our Local Distributor
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北京 101111
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Quick Overview for SMC6 抗体 (N-Term) (ABIN5672641)
抗原
See all SMC6 抗体
SMC6
(SMC6 Structural Maintenance of Chromosomes 6-Like 1 (SMC6))
适用
人
宿主
兔
克隆类型
多克隆
标记
This SMC6 antibody is un-conjugated
应用范围
Western Blotting (WB)
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抗原表位
- N-Term
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序列
- NFSSPKNAKR PRQEELEDFD KDGDEDECKG TTLTAAEVGI IESIHLKNFM
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纯化方法
- Affinity purified
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免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human SMC6
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anti-SMC6 Structural Maintenance of Chromosomes 6-Like 1 (SMC6) (AA 1-110) antibody
SMC6 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2E6 unconjugated
anti-SMC6 Structural Maintenance of Chromosomes 6-Like 1 (SMC6) (AA 309-450) antibodySMC6 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- SMC6 (SMC6 Structural Maintenance of Chromosomes 6-Like 1 (SMC6))
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别名
- SMC6
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背景
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Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome.
Alias Symbols: SMC-6, hSMC6, SMC6L1
Protein Size: 1091 -
基因ID
- 79677
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NCBI登录号
- NM_001142286, NP_001135758
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UniProt
- Q96SB8
抗原
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