EIF3B 抗体 (N-Term)
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Quick Overview for EIF3B 抗体 (N-Term) (ABIN5672523)
抗原
See all EIF3B 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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序列
- AAEELPGSHA EPPVPAQGEA PGEQARDERS DSRAQAVSED AGGNEGRAAE
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纯化方法
- Affinity purified
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免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human EIF3B
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- EIF3B (Eukaryotic Translation Initiation Factor 3, Subunit B (EIF3B))
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别名
- EIF3B
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背景
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RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.(Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2.
Alias Symbols: PRT1, EIF3S9, EIF3-ETA, EIF3-P110, EIF3-P116
Protein Size: 873 -
基因ID
- 8662
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NCBI登录号
- NM_001037283, NP_001032360
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途径
- Ribonucleoprotein Complex Subunit Organization
抗原
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