EXOSC5 抗体 (N-Term)
Quick Overview for EXOSC5 抗体 (N-Term) (ABIN5672011)
抗原
See all EXOSC5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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序列
- CSLRHFACEQ NLLSRPDGSA SFLQGDTSVL AGVYGPAEVK VSKEIFNKAT
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预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 91%
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产品特性
- This is a rabbit polyclonal antibody against EXOS5. It was validated on Western Blot.
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纯化方法
- Affinity purified
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免疫原
- The immunogen is a synthetic peptide directed towards the N-terminal region of Human EXOS5
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anti-Exosome Component 5 (EXOSC5) (AA 1-235) antibody
EXOSC5 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Exosome Component 5 (EXOSC5) (AA 1-235) antibodyEXOSC5 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Exosome Component 5 (EXOSC5) (AA 1-100) antibodyEXOSC5 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 1E11 unconjugated
anti-Exosome Component 5 (EXOSC5) (AA 1-235) antibodyEXOSC5 适用: 人 ELISA, IF 宿主: 小鼠 Monoclonal 6G11 unconjugated
anti-Exosome Component 5 (EXOSC5) (AA 1-235) antibodyEXOSC5 适用: 人 IP 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- EXOSC5 (Exosome Component 5 (EXOSC5))
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别名
- EXOS5
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背景
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EXOS5 is a non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation .
Alias Symbols: EXOSC5, CML28, RRP46,
Protein Interaction Partner: DOCK8, TRIM54, EXOSC1, FCHO1, IKZF3, EXOSC8, CALCOCO2, TNFAIP1, REL, KRT13, GOLGA2, BIRC2, UBC, rev, ZNF558, CDK5RAP1, EXOSC3, SRPK3, POLR2L, EXOSC10, PA2G4, LIPG, AICDA, DHRS2, EXOSC4, EXOSC2, PSIP1, EXOSC9, DIS3L, DIS3, CUL3, MEPCE, CDK9, SKIV2L2, EXOSC
Protein Size: 235 -
基因ID
- 56915
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NCBI登录号
- NP_064543
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UniProt
- Q9NQT4
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途径
- SARS-CoV-2 Protein Interactome
抗原
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