Recombinant ITGA5 (Volociximab Biosimilar) 抗体
This anti- antibody is a 兔 Chimeric antibody detecting in BR, ELISA, FACS, IF 和 IHC. Suitable for 人.
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Quick Overview for Recombinant ITGA5 (Volociximab Biosimilar) 抗体 (ABIN5668271)
抗原
ITGA5 (Volociximab Biosimilar)
抗体类型
Recombinant Antibody
适用
人
宿主
兔
克隆类型
Chimeric
标记
非结合性
应用范围
Blocking Reagent (BR), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC)
克隆位点
M200
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原理
- Anti-alpha 5 beta 1 Integrin [M200 (Volociximab)], Rabbit IgG, kappa
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特异性
- The antibody binds to human α5β1 integrin with a Kd of 0.367 nM (determined by Biacore), an EC50 of 0.2 nM and an IC50 of 2.3 nM.
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产品特性
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Original Species of Ab: Human
Original Format of Ab: IgG4
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纯化方法
- Protein A affinity purified
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纯度
- > 98 % as determined by SDS-PAGE
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内毒素水平
- Endotoxin is < 1.0 EU/mg as determined by the LAL method
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免疫原
- Heterodimeric alpha5beta1Fc fusion protein
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亚型
- IgG kappa
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应用备注
- The antibody binds specifically to α5β1 integrin, which is part of the superfamily of glycoprotein transmembrane receptors for ligands such as fibronectin, vitronectin, laminins and collagens. The α5β1 integrin receptor plays a key role in cellular processes such as inflammation, cell proliferation, angiogenesis and tumour metastasis. Comprising the variable domain of the original mouse antibody, a chimeric mouse:human IgG4 version of this antibody has been tested in vivo: In cynomolgus monkeys with laser-induced choroidal neovascularization (CNV), in rabbit models and in human volunteers. The antibody reached Phase II clinical trials with PDL Biopharma and Biogen-Idec.
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说明
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NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar. This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG4 format, for improved compatibility with existing reagents, assays and techniques.
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % Proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- ITGA5 (Volociximab Biosimilar)
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物质类
- Biosimilar
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背景
- Fibronectin receptor, CD49 antigen-like family member E, Integrin alpha-F, VLA-5, CD49e.
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UniProt
- P08648
抗原
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