Recombinant CD19 抗体
Quick Overview for Recombinant CD19 抗体 (ABIN5668221)
抗原
See all CD19 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Anti-CD19 [FMC63], Rabbit IgG, kappa
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特异性
- This antibody is specific for human CD19, a 95 kDa protein expressed in the B-lymphocyte lineage.
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产品特性
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Original Species of Ab: Mouse
Original Format of Ab: IgG2a
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纯化方法
- Protein A affinity purified
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免疫原
- Human prolymphocytic leukaemia cell line JVM3.
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亚型
- IgG kappa
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anti-CD19 Molecule (CD19) (AA 151-250) antibody
CD19 适用: 人, 小鼠, 大鼠 FACS, WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-CD19 Molecule (CD19) (AA 20-291) antibodyCD19 适用: 人 FACS, WB, IHC, IF, ELISA 宿主: 小鼠 Monoclonal 8G11B7 unconjugated
anti-CD19 Molecule (CD19) (C-Term) antibodyCD19 适用: 人, 小鼠, 大鼠, 猴, 绵羊, Pig, Cow, 豚鼠, 兔, 犬, Avian, Cat, 小鸡, 驴, 山羊, Hamster, 马 WB 宿主: 山羊 Polyclonal unconjugated
anti-CD19 Molecule (CD19) (AA 485-556) antibodyCD19 适用: 人, 小鼠, 大鼠, 绵羊 FACS, ELISA, IHC (fro), IHC (p), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-CD19 Molecule (CD19) (pTyr531) antibodyCD19 适用: 人, 小鼠 FACS, ELISA, IHC (fro), IHC (p), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-CD19 Molecule (CD19) (AA 96-281) antibodyCD19 适用: 人 FACS, IHC, ELISA, Coat, StM 宿主: 小鼠 Monoclonal CD19-3116 unconjugated
anti-CD19 Molecule (CD19) antibodyCD19 适用: 人 FACS, WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-CD19 Molecule (CD19) (AA 143-172) antibodyCD19 适用: 人 FACS, WB, IHC, IF, ELISA 宿主: 兔 Polyclonal unconjugated
anti-CD19 Molecule (CD19) (AA 160-258) antibodyCD19 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-CD19 Molecule (CD19) (AA 20-291) antibodyCD19 适用: 人 FACS, WB, IHC, ELISA 宿主: 小鼠 Monoclonal 4C6G1 unconjugated
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应用备注
- FMC63 was used for four years as a CD19 antibody in various labs prior to its original publication. There, it was reported that the antibody percipitates CD19 and inhibits the binding of other CD19 antibodies to it (Zola et al., 1991, PMID: 1725979). FMC63 was used for IF and FACS of peripheral blood mononuclear cells (PBMC) from patients with multiple myeloma (MM) (Szczepek et al., 1997, PMID: 9057669) and receptor for hyaluronan (HA)-mediated motility (RHAMM) expressing malignant B-lineage cells in myeloma (Crainie et al., 1999, PMID: 10029598). FMC63 was used for IHC and IIP of B cells in lymphocyte-filled villi and IIP of jejunal isolated lymphoid follicle, respectively, in small bowel specimens from human patients (Moghaddami et al., 1998, PMID: 9834269). FNC63 was used to induce B cell depletion in vivo (DiLillo et al., 2011, PMID: 21248259). FMC63 has been incorporated into a CD19 scFv- 41BB- CD3ζ fusion protein-encoding lentiviral vector, which was used in combination with a UCART19 cell therapy to cure high-risk CD19+ infant acute lymphoblastic leukemia (< a href="https://www.sciencedirect.com/science/article/pii/S0006497119817871" target="_blank">Qasim et al., 2017). This clone did not compete with clone HD37 (available as Ab00214) (Sakemura et al., 2023, PMID: 37879074).
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说明
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This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % Proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- CD19 (CD19 Molecule (CD19))
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别名
- CD19
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背景
- B-lymphocyte antigen CD19, B-lymphocyte surface antigen B4, Differentiation antigen CD19, Leu12, T-cell surface antigen Leu-12
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UniProt
- P15391
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途径
- Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
抗原
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