Recombinant RSV (Felvizumab Biosimilar) 抗体
This anti-RSV (Felvizumab Biosimilar) antibody is a 兔 Chimeric antibody detecting RSV (Felvizumab Biosimilar) in ELISA 和 Func. Suitable for Respiratory Syncytial Virus (RSV).
Quick Overview for Recombinant RSV (Felvizumab Biosimilar) 抗体 (ABIN5668207)
抗原
RSV (Felvizumab Biosimilar)
抗体类型
Recombinant Antibody
适用
Respiratory Syncytial Virus (RSV)
宿主
兔
克隆类型
Chimeric
标记
This RSV (Felvizumab Biosimilar) antibody is un-conjugated
应用范围
ELISA, Functional Studies (Func)
克隆位点
RSHZ19
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原理
- Anti-RSV [RSHZ19 (Felvizumab)], Rabbit IgG, kappa
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特异性
- This antibody is specific for the an epitope located between amino acids 417-432 of conserved fusion (F) protein of RSV.
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产品特性
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Original Species of Ab: Human
Original Format of Ab: IgG1
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纯化方法
- Protein A affinity purified
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纯度
- > 98 % as determined by SDS-PAGE
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内毒素水平
- Endotoxin is < 1.0 EU/mg as determined by the LAL method
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免疫原
- This antibody was prepared by the humanization of an F protein-specific murine MAb, RSV19. More specifically, molecular techniques were used to insert the complementarity determining regions from murine RSV19 into a human IgG1 heavy and k light chain-variable domain framework.
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亚型
- IgG kappa
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应用备注
- Though shown to be safe and well-tolerated (Everitt, 1996) and protective against RSV infection in BALB/c mice and cotton rats (Wyde, 1995), this antibody did not demonstrate efficacy in a Phase 3 study (Reichert, 2008). In in vitro studies, palivizumab, another humanized Mab specific for the F protein of RSV, was 4 to 5-fold more potent than felvizumab in neutralising RSV (Scott, 1999).
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说明
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This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % Proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- RSV (Felvizumab Biosimilar)
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物质类
- Biosimilar
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背景
- SB 209763, respiratory syncytial virus
抗原
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