Recombinant ITGA4 (Natalizumab Biosimilar) 抗体
(1 reference)Quick Overview for Recombinant ITGA4 (Natalizumab Biosimilar) 抗体 (ABIN5668196)
抗原
抗体类型
适用
宿主
克隆类型
标记
应用范围
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原理
- Anti-Integrin alpha 4 [Natalizumab], Human IgG4, kappa
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特异性
- This antibody binds to the alpha 4 binds subunit of α4β1 (also known as very late antigen 4 [VLA-4] or CD49d-CD29) and α4β7 integrin
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产品特性
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Original Species of Ab: Human
Original Format of Ab: IgG4
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纯化方法
- Protein A affinity purified
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纯度
- > 98 % as determined by SDS-PAGE
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内毒素水平
- Endotoxin is < 1.0 EU/mg as determined by the LAL method
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免疫原
- The RAMOS cell line, a non-EBV releasing cell line, injected into mice.
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亚型
- IgG4 kappa
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anti-ITGA4 (Natalizumab Biosimilar) antibody
Research Grade 适用: 人 FACS 宿主: Humanized Monoclonal unconjugated Recombinant Antibody
anti-ITGA4 (Natalizumab Biosimilar) antibody适用: 人 FACS, BR 宿主: 兔 Chimeric unconjugated Recombinant Antibody
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应用备注
- This antibody binds to human integrin alpha 4 and has been used to treat Multiple Sclerosis and Crohn's Disease.
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说明
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NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar.
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % Proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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: "An innovative strategy to identify new targets for delivering antibodies to the brain has led to the exploration of the integrin family." in: PloS one, Vol. 17, Issue 9, pp. e0274667, (2022) (PubMed).
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: "An innovative strategy to identify new targets for delivering antibodies to the brain has led to the exploration of the integrin family." in: PloS one, Vol. 17, Issue 9, pp. e0274667, (2022) (PubMed).
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- ITGA4 (Natalizumab Biosimilar)
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背景
- CD49D, alpha 4 subunit of VLA-4 receptor, ITGA4, Integrin alpha-IV
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UniProt
- P13612
抗原
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