Recombinant TNF alpha (Adalimumab Biosimilar) 抗体
This anti-TNF alpha (Adalimumab Biosimilar) antibody is a 兔 Chimeric antibody detecting TNF alpha (Adalimumab Biosimilar) in ELISA, BR, IF 和 IHC. Suitable for 人.
Quick Overview for Recombinant TNF alpha (Adalimumab Biosimilar) 抗体 (ABIN5668146)
抗原
TNF alpha (Adalimumab Biosimilar)
抗体类型
Recombinant Antibody
适用
人
宿主
兔
克隆类型
Chimeric
标记
This TNF alpha (Adalimumab Biosimilar) antibody is un-conjugated
应用范围
ELISA, Blocking Reagent (BR), Immunofluorescence (IF), Immunohistochemistry (IHC)
克隆位点
D2E7
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原理
- Anti-TNF alpha [D2E7 (Adalimumab)], Rabbit IgG, kappa
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特异性
- Binds to soluble TNF-alpha, but not to lymphotoxin (TNF beta).
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交叉反应
- 小鼠
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产品特性
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Original Species of Ab: Human
Original Format of Ab: IgG1
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纯化方法
- Protein A affinity purified
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纯度
- > 98 % as determined by SDS-PAGE
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内毒素水平
- Endotoxin is < 1.0 EU/mg as determined by the LAL method
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免疫原
- This antibody was generated by affinity maturation from the 2SD4 scFv, which in turn was selected on human TNF alpha by guided phage-display technology, using the murine anti-hTNF alpha antibody Mab32 as a template (c.f. also US Patent 6090382).
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亚型
- IgG kappa
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anti-TNF alpha (Adalimumab Biosimilar) antibody
Research Grade 适用: 人 ELISA, FACS 宿主: Human Monoclonal unconjugated Recombinant Antibody
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应用备注
- Adalimumab binds specifically to TNF and neutralizes the biological function of TNF by blocking its interaction with the p55 and p75 cell surface TNF receptors. Adalimumab, unlike Infliximab (Ab00146), was shown to be cross-reactive with mouse TNF alpha (Arnoult 2017, PMID: 28584008).
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说明
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NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar. This chimeric rabbit antibody was made using the variable domain sequences of the original human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % Proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- TNF alpha (Adalimumab Biosimilar)
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物质类
- Biosimilar
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背景
- Tumor necrosis factor alpha
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UniProt
- P01375
抗原
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