Recombinant TNF alpha (Humicade Biosimilar) 抗体
This anti- antibody is a Human 单克隆 antibody detecting in ELISA. Suitable for 人.
Quick Overview for Recombinant TNF alpha (Humicade Biosimilar) 抗体 (ABIN5668143)
抗原
TNF alpha (Humicade Biosimilar)
抗体类型
Recombinant Antibody
适用
人
宿主
Human
克隆类型
单克隆
标记
非结合性
应用范围
ELISA
克隆位点
CDP 571
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原理
- Anti-TNF alpha [CDP 571 (Humicade)], Human IgG4, kappa
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特异性
- The antibody binds to human TNF-alpha with a Kd of 0.087 nM.
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产品特性
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Original Species of Ab: Human
Original Format of Ab: IgG4
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纯化方法
- Protein A affinity purified
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纯度
- > 98 % as determined by SDS-PAGE
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内毒素水平
- Endotoxin is < 1.0 EU/mg as determined by the LAL method
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免疫原
- Human TNF-alpha
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亚型
- IgG4 kappa
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应用备注
- The antibody binds specifically to TNF-alpha, a pro-inflammatory cytokine which stimulates release of other cytiokines e.g. IL-1, IL-6 and GM-CSF as well as secretion of ICAM-1 and VCAM-1 from endothelial cells. It stimulates acute phase responses and acts as a chemoattractant for NK cells and monocytes/macrophages. The antibody reached Phase II clinical trials with Celltech, UCB.
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说明
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NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar.
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % Proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- TNF alpha (Humicade Biosimilar)
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物质类
- Biosimilar
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背景
- TNFA, Tumour necrosis factor superfamily member 2, TNFSF2
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UniProt
- P01375
抗原
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