ALKBH7 抗体 (AA 1-221)
This 兔 多克隆 anti-ALKBH7 antibody specifically detects ALKBH7 in WB. The antibody is reactive with 人 samples.
产品编号 ABIN5664063
发货至:
中国
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Contact Info
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北京 101111
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Quick Overview for ALKBH7 抗体 (AA 1-221) (ABIN5664063)
抗原
See all ALKBH7 抗体
ALKBH7
(AlkB, Alkylation Repair Homolog 7 (ALKBH7))
适用
人
宿主
兔
克隆类型
多克隆
标记
This ALKBH7 antibody is un-conjugated
应用范围
Western Blotting (WB)
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抗原表位
- AA 1-221
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序列
- MAGTGLLALR TLPGPSWVRG SGPSVLSRLQ DAAVVRPGFL STAEEETLSR ELEPELRRRR YEYDHWDAAI HGFRETEKSR WSEASRAILQ RVQAAAFGPG QTLLSSVHVL DLEARGYIKP HVDSIKFCGA TIAGLSLLSP SVMRLVHTQE PGEWLELLLE PGSLYILRGS ARYDFSHEIL RDEESFFGER RIPRGRRISV ICRSLPEGMG PGESGQPPPA C
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交叉反应
- 人, 小鼠, 大鼠
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产品特性
- Polyclonal Antibodies
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纯化方法
- Affinity purification
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免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-221 of human ALKBH7 (NP_115682.1).
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亚型
- IgG
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应用备注
- WB,1:200 - 1:2000
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限制
- 仅限研究用
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- ALKBH7 (AlkB, Alkylation Repair Homolog 7 (ALKBH7))
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别名
- ALKBH7
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背景
- May function as protein hydroxylase, can catalyze auto-hydroxylation at Leu-110 (in vitro, but this activity may be due to the absence of the true substrate. Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does not display DNA demethylase activity. Involved in fatty acid metabolism (By similarity.,ALKBH7,ABH7,SPATA11,UNQ6002,Epigenetics & Nuclear Signaling,DNA Damage & Repair,ALKBH7
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分子量
- 24 kDa
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基因ID
- 84266
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UniProt
- Q9BT30
抗原
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