AANAT
适用: 人, 大鼠, 小鼠
IF (cc), IF (p)
宿主: 兔
Polyclonal
Cy7
应用备注
Western blot: 1:1000
限制
仅限研究用
缓冲液
In 1X PBS, pH 7.4, with 0.09 % sodium azide
储存液
Sodium azide
注意事项
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
-20 °C
储存方法
Aliquot the AANAT antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
抗原
AANAT
(Aralkylamine N-Acetyltransferase (AANAT))
别名
AANAT
背景
Serotonin N-acetyltransferase/AANAT belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome.