PVRL4 抗体 (AA 53-94)
Our Local Distributor
北京 101111
Quick Overview for PVRL4 抗体 (AA 53-94) (ABIN5647906)
抗原
See all PVRL4 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 53-94
-
纯化方法
- Antigen affinity purified
-
免疫原
- Amino acids 53-94 (FYRGDSGEQVGQVAWARVDAGEGAQELALLHSKYGLHVSPAY) from the human protein were used as the immunogen for the Nectin-4 antibody.
-
亚型
- IgG
-
-
-
-
应用备注
- Western blot: 0.5-1 μg/mL
-
限制
- 仅限研究用
-
-
-
缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
-
储存条件
- -20 °C
-
储存方法
- After reconstitution, the Nectin-4 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
-
-
- PVRL4 (Poliovirus Receptor-Related 4 (PVRL4))
-
别名
- Nectin-4 / PVRL4
-
背景
- PVRL4, also known as Nectin-4, is expressed in human skin, hair follicles, and cultured keratinocytes, but not in fibroblasts. This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.
-
UniProt
- Q96NY8
-
途径
- Cell-Cell Junction Organization
抗原
-