CD16 抗体
Quick Overview for CD16 抗体 (ABIN5647428)
抗原
See all CD16 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应 (详细)
- Expected species reactivity: Human
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纯化方法
- Antigen affinity purified
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免疫原
- A recombinant human protein corresponding to amino acids Q101-D166 was used as the immunogen for the CD16 antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the CD16 antibody should be determined by the researcher.\. Western Blot: 0.5-1 μg/mL,Direct ELISA: 0.1-0.5 μg/mL
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限制
- 仅限研究用
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- -20 °C
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储存方法
- After reconstitution, the CD16 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
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- CD16
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别名
- CD16
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背景
- Low affinity immunoglobulin gamma Fc region receptor III-A is a protein that in humans is encoded by the FCGR3A gene. This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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UniProt
- P08637
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途径
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
抗原
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