AIRE 抗体
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北京 101111
Quick Overview for AIRE 抗体 (ABIN5647007)
抗原
See all AIRE 抗体适用
宿主
克隆类型
标记
应用范围
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纯化方法
- Antigen affinity purified
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免疫原
- Amino acids M1-K120 from the human protein were used as the immunogen for the AIRE antibody.
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亚型
- IgG
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应用备注
- Western blot: 0.5-1 μg/mL,FACS: 1-3 μg/10^6 cells
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限制
- 仅限研究用
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- -20 °C
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储存方法
- Prior to reconstitution, store at 4°C. After reconstitution, the AIRE antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
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- AIRE (Autoimmune Regulator (AIRE))
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别名
- AIRE
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背景
- The autoimmune regulator (AIRE) is a protein that in humans is encoded by the AIRE gene. This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED).
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UniProt
- O43918
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途径
- Chromatin Binding
抗原
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