ATRX 抗体 (AA 2311-2492)
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北京 101111
Quick Overview for ATRX 抗体 (AA 2311-2492) (ABIN5611354)
抗原
See all ATRX 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 2311-2492
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原理
- ATRX Antibody
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纯化方法
- Purified antibody
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免疫原
- Purified recombinant fragment of human ATRX (AA: 2311-2492) expressed in E. Coli.
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亚型
- IgG1
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应用备注
- ELISA: 1/10000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified antibody in PBS with 0.05 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- ATRX (helicase 2, X-linked (ATRX))
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别名
- ATRX
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背景
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The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
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分子量
- 282.5 kDa
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基因ID
- 546
抗原
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