CHRNA4 抗体 (AA 29-242)
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北京 101111
Quick Overview for CHRNA4 抗体 (AA 29-242) (ABIN5611309)
抗原
See all CHRNA4 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 29-242
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原理
- CHRNA4 Antibody
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纯化方法
- Purified antibody
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免疫原
- Purified recombinant fragment of human CHRNA4 (AA: 29-242) expressed in E. Coli.
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亚型
- IgG1
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应用备注
- ELISA: 1/10000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified antibody in PBS with 0.05 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- CHRNA4 (Cholinergic Receptor, Nicotinic, alpha 4 (CHRNA4))
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别名
- CHRNA4
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背景
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This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants.
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分子量
- 70 kDa
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基因ID
- 1137
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UniProt
- P43681
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途径
- Synaptic Membrane
抗原
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