SLAMF7 抗体 (AA 23-226)
Quick Overview for SLAMF7 抗体 (AA 23-226) (ABIN5611285)
抗原
See all SLAMF7 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 23-226
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原理
- CD319 Antibody
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纯化方法
- Purified antibody
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免疫原
- Purified recombinant fragment of human CD319 (AA: 23-226) expressed in E. Coli.
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亚型
- IgG1
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anti-SLAM Family Member 7 (SLAMF7) (AA 51-160) antibody
SLAMF7 适用: 人, 小鼠 WB, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-SLAM Family Member 7 (SLAMF7) (AA 23-226) antibodySLAMF7 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-SLAM Family Member 7 (SLAMF7) (AA 1-296) antibodySLAMF7 适用: 人 ELISA, IF 宿主: 小鼠 Monoclonal 1B9 unconjugated
anti-SLAM Family Member 7 (SLAMF7) (AA 1-335) antibodySLAMF7 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-SLAM Family Member 7 (SLAMF7) (AA 1-296) antibodySLAMF7 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-SLAM Family Member 7 (SLAMF7) (AA 23-175) antibodySLAMF7 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1/10000
FCM: 1/200 - 1/400
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified antibody in PBS with 0.05 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- SLAMF7 (SLAM Family Member 7 (SLAMF7))
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别名
- CD319
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背景
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"Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed:23695528).
Isoform 3 does not mediate any NK cell activation."
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分子量
- 37.4 kDa
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基因ID
- 57823
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UniProt
- Q9NQ25
抗原
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