IGHM 抗体 (AA 310-452)
Quick Overview for IGHM 抗体 (AA 310-452) (ABIN5611170)
抗原
适用
宿主
克隆类型
标记
应用范围
克隆位点
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    - 
                                            抗原表位
- AA 310-452
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                                            原理
- IGHM Antibody
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                                            纯化方法
- Purified antibody
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                                            免疫原
- Purified recombinant fragment of human IGHM (AA: 310-452) expressed in E. Coli.
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                                            亚型
- IgG1
 
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                                            应用备注
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                        ELISA: 1/10000 FCM: 1/200 - 1/400 
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                                            限制
- 仅限研究用
 
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                                            状态
- Liquid
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                                            缓冲液
- Purified antibody in PBS with 0.05 % sodium azide.
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                                            储存液
- Sodium azide
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                                            注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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                                            储存条件
- 4 °C,-20 °C
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                                            储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
 
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    - IGHM (Immunoglobulin Heavy Constant mu (IGHM))
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                                            别名
- IGHM
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                                            背景
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                        Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains and 2 identical light chains (see MIM 147200) joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by an individual C region gene, that determines the isotype of the antibody and provides effector or signaling functions. The heavy chain V region is encoded by 1 each of 3 types of genes: V genes (see MIM 147070), joining (J) genes (see MIM 147010), and diversity (D) genes (see MIM 146910). The C region genes are clustered downstream of the V region genes within the heavy chain locus on chromosome 14. The IGHM gene encodes the C region of the mu heavy chain, which defines the IgM isotype. Naive B cells express the transmembrane forms of IgM and IgD (see IGHD, MIM 1471770) on their surface. During an antibody response, activated B cells can switch to the expression of individual downstream heavy chain C region genes by a process of somatic recombination known as isotype switching. In addition, secreted Ig forms that act as antibodies can be produced by alternative RNA processing of the heavy chain C region sequences. Although the membrane forms of all Ig isotypes are monomeric, secreted IgM forms pentamers, and occasionally hexamers, in plasma (summary by Janeway et al., 2005).
 
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                                            分子量
- 49.3 kDa
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                                            UniProt
- P01871
 抗原
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