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IGHM 抗体 (AA 310-452)

IGHM 适用: 人 IHC, WB, FACS, ELISA 宿主: 小鼠 Monoclonal 8B9D3 unconjugated
产品编号 ABIN5611170
发货至: 中国
  • 抗原 See all IGHM products
    IGHM (Immunoglobulin Heavy Constant mu (IGHM))
    抗原表位
    • 5
    • 2
    • 2
    • 1
    • 1
    AA 310-452
    适用
    • 27
    • 1
    • 1
    宿主
    • 14
    • 13
    小鼠
    克隆类型
    • 17
    • 10
    单克隆
    标记
    • 23
    • 1
    • 1
    • 1
    • 1
    This IGHM antibody is un-conjugated
    应用范围
    • 14
    • 13
    • 11
    • 7
    • 7
    • 7
    • 6
    • 4
    • 2
    • 1
    • 1
    Immunohistochemistry (IHC), Western Blotting (WB), Flow Cytometry (FACS), ELISA
    原理
    IGHM Antibody
    纯化方法
    Purified antibody
    免疫原
    Purified recombinant fragment of human IGHM (AA: 310-452) expressed in E. Coli.
    克隆位点
    8B9D3
    亚型
    IgG1
  • 应用备注

    ELISA: 1/10000

    FCM: 1/200 - 1/400

    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified antibody in PBS with 0.05 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • 抗原
    IGHM (Immunoglobulin Heavy Constant mu (IGHM))
    别名
    IGHM (IGHM 产品)
    背景
    Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains and 2 identical light chains (see MIM 147200) joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by an individual C region gene, that determines the isotype of the antibody and provides effector or signaling functions. The heavy chain V region is encoded by 1 each of 3 types of genes: V genes (see MIM 147070), joining (J) genes (see MIM 147010), and diversity (D) genes (see MIM 146910). The C region genes are clustered downstream of the V region genes within the heavy chain locus on chromosome 14. The IGHM gene encodes the C region of the mu heavy chain, which defines the IgM isotype. Naive B cells express the transmembrane forms of IgM and IgD (see IGHD, MIM 1471770) on their surface. During an antibody response, activated B cells can switch to the expression of individual downstream heavy chain C region genes by a process of somatic recombination known as isotype switching. In addition, secreted Ig forms that act as antibodies can be produced by alternative RNA processing of the heavy chain C region sequences. Although the membrane forms of all Ig isotypes are monomeric, secreted IgM forms pentamers, and occasionally hexamers, in plasma (summary by Janeway et al., 2005).
    分子量
    49.3 kDa
    UniProt
    P01871
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