RASGRP2 抗体 (C-Term)
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北京 101111
Quick Overview for RASGRP2 抗体 (C-Term) (ABIN5564284)
抗原
See all RASGRP2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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原理
- anti-RasGRP2, pAb (IG-09)
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特异性
- Recognizes human and mouse RasGRP2.
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产品特性
- Polyclonal Antibody. Recognizes human and mouse RasGRP2. Source: Rabbit. Applications: WB. Liquid. In PBS containing 2 mg/mL BSA and 0.05 % sodium azide. RasGRP2 functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating small GTPases, including Rap1/RAS3, through the exchange of bound GDP for GTP. It may also activate other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. The protein is expressed in platelets, neutrophils and T lymphocytes. RasGRP2 functions in aggregation of platelets and adhesion of T lymphocytes and neutrophils probably through inside-out integrin activation. S587 was identified as the major PKA phosphorylation. Phosphorylation of S587 correlated with the inhibitory effect of PKA on Rap1b activation in platelets. In vitro, ERK1/2 phosphorylates RasGRP2 at Ser394 to limit its exchange activity and inhibits its ability to activate the small GTPase Rap1 that ultimately leads to decreased activation of ERK1/2 in cells.
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纯化方法
- Antigen affinity purified.
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纯度
- Antigen affinity purified.
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免疫原
- Synthetic peptide corresponding to a human RasGRP2 sequence located at the C-terminus of the RasGEF domain.
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anti-RAS Guanyl Releasing Protein 2 (Calcium and DAG-Regulated) (RASGRP2) (AA 65-164) antibody
RASGRP2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3D8 unconjugated
anti-RAS Guanyl Releasing Protein 2 (Calcium and DAG-Regulated) (RASGRP2) (AA 7-34), (N-Term) antibodyRASGRP2 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB32230 unconjugated
anti-RAS Guanyl Releasing Protein 2 (Calcium and DAG-Regulated) (RASGRP2) (AA 65-164) antibodyRASGRP2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-RAS Guanyl Releasing Protein 2 (Calcium and DAG-Regulated) (RASGRP2) (AA 1-671) antibodyRASGRP2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-RAS Guanyl Releasing Protein 2 (Calcium and DAG-Regulated) (RASGRP2) antibodyRASGRP2 适用: 人 WB, IHC, IF/ICC 宿主: 兔 Polyclonal unconjugated
anti-RAS Guanyl Releasing Protein 2 (Calcium and DAG-Regulated) (RASGRP2) (AA 35-84) antibodyRASGRP2 适用: 人, 大鼠, 犬, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-RAS Guanyl Releasing Protein 2 (Calcium and DAG-Regulated) (RASGRP2) (AA 299-609) antibodyRASGRP2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-RAS Guanyl Releasing Protein 2 (Calcium and DAG-Regulated) (RASGRP2) antibodyRASGRP2 适用: 人, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-RAS Guanyl Releasing Protein 2 (Calcium and DAG-Regulated) (RASGRP2) antibodyRASGRP2 适用: 人, 小鼠, 大鼠 ELISA 宿主: 兔 Polyclonal unconjugated
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In PBS containing 2 mg/mL BSA and 0.05 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Do not freeze.Keep sterile.
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储存条件
- 4 °C
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储存方法
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+4°C
+4°C
Stable for at least 6 months after receipt when stored at +4°C.
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有效期
- 6 months
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- RASGRP2 (RAS Guanyl Releasing Protein 2 (Calcium and DAG-Regulated) (RASGRP2))
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别名
- RasGRP2
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背景
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Alternate Names/Synonyms: CalDAG-GEFI, Ras Guanyl Nucleotide-releasing Protein 2, Ras Guanyl Releasing Protein 2, CDC25-like Protein, CDC25L, Calcium and DAG-regulated Guanine Nucleotide Exchange Factor I, MCG7
Product Description: RasGRP2 functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating small GTPases, including Rap1/RAS3, through the exchange of bound GDP for GTP. It may also activate other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. The protein is expressed in platelets, neutrophils and T lymphocytes. RasGRP2 functions in aggregation of platelets and adhesion of T lymphocytes and neutrophils probably through inside-out integrin activation. S587 was identified as the major PKA phosphorylation. Phosphorylation of S587 correlated with the inhibitory effect of PKA on Rap1b activation in platelets. In vitro, ERK1/2 phosphorylates RasGRP2 at Ser394 to limit its exchange activity and inhibits its ability to activate the small GTPase Rap1 that ultimately leads to decreased activation of ERK1/2 in cells.
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UniProt
- Q7LDG7
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途径
- TCR Signaling
抗原
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