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ARF1 抗体

ARF1 适用: 人, 大鼠, 小鼠 WB, IF (cc) 宿主: 兔 Monoclonal 1D4 unconjugated
产品编号 ABIN5557419
发货至: 中国
  • 抗原 See all ARF1 抗体
    ARF1 (ADP-Ribosylation Factor 1 (ARF1))
    适用
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    人, 大鼠, 小鼠
    宿主
    • 64
    • 13
    • 1
    克隆类型
    • 57
    • 21
    单克隆
    标记
    • 34
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    This ARF1 antibody is un-conjugated
    应用范围
    • 33
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    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc))
    纯化方法
    Purified by Protein A.
    免疫原
    Recombinant human ARF1 protein, full length.
    克隆位点
    1D4
    亚型
    IgG
    Top Product
    Discover our top product ARF1 Primary Antibody
  • 应用备注
    WB 1:1000-2000
    IF(ICC) 1:50-200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
    储存条件
    -20 °C
    储存方法
    Store at -20°C
    有效期
    12 months
  • 抗原
    ARF1 (ADP-Ribosylation Factor 1 (ARF1))
    别名
    ARF1 (ARF1 产品)
    背景

    GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity, the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD).

    Synonyms: ADP-ribosylation factor 1, ARF1

    基因ID
    375
    UniProt
    P84077
    途径
    Transition Metal Ion Homeostasis, Inositol Metabolic Process
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