ARF1 抗体
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- 抗原 See all ARF1 抗体
- ARF1 (ADP-Ribosylation Factor 1 (ARF1))
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适用
- 人, 大鼠, 小鼠
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宿主
- 兔
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克隆类型
- 单克隆
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标记
- This ARF1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc))
- 纯化方法
- Purified by Protein A.
- 免疫原
- Recombinant human ARF1 protein, full length.
- 克隆位点
- 1D4
- 亚型
- IgG
- Top Product
- Discover our top product ARF1 Primary Antibody
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- 应用备注
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WB 1:1000-2000
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C
- 有效期
- 12 months
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- 抗原
- ARF1 (ADP-Ribosylation Factor 1 (ARF1))
- 别名
- ARF1 (ARF1 产品)
- 背景
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GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity, the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD).
Synonyms: ADP-ribosylation factor 1, ARF1
- 基因ID
- 375
- UniProt
- P84077
- 途径
- Transition Metal Ion Homeostasis, Inositol Metabolic Process
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