ARF1 抗体
Quick Overview for ARF1 抗体 (ABIN5557419)
抗原
See all ARF1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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纯化方法
- Purified by Protein A.
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免疫原
- Recombinant human ARF1 protein, full length.
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亚型
- IgG
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应用备注
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WB 1:1000-2000
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
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储存条件
- -20 °C
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储存方法
- Store at -20°C
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有效期
- 12 months
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- ARF1 (ADP-Ribosylation Factor 1 (ARF1))
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别名
- ARF1
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背景
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GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity, the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD).
Synonyms: ADP-ribosylation factor 1, ARF1
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基因ID
- 375
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UniProt
- P84077
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途径
- Transition Metal Ion Homeostasis, Inositol Metabolic Process
抗原
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