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ARF1 抗体

This anti-ARF1 antibody is a 兔 单克隆 antibody detecting ARF1 in WB 和 IF (cc). Suitable for 人, 大鼠 和 小鼠.
产品编号 ABIN5557419
发货至: 中国

Quick Overview for ARF1 抗体 (ABIN5557419)

抗原

See all ARF1 抗体
ARF1 (ADP-Ribosylation Factor 1 (ARF1))

适用

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人, 大鼠, 小鼠

宿主

  • 68
  • 43
  • 1

克隆类型

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  • 53
单克隆

标记

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This ARF1 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc))

克隆位点

1D4
  • 纯化方法

    Purified by Protein A.

    免疫原

    Recombinant human ARF1 protein, full length.

    亚型

    IgG
  • 应用备注

    WB 1:1000-2000
    IF(ICC) 1:50-200

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

    储存条件

    -20 °C

    储存方法

    Store at -20°C

    有效期

    12 months
  • 抗原

    ARF1 (ADP-Ribosylation Factor 1 (ARF1))

    别名

    ARF1

    背景

    GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity, the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD).

    Synonyms: ADP-ribosylation factor 1, ARF1

    基因ID

    375

    UniProt

    P84077

    途径

    Transition Metal Ion Homeostasis, Inositol Metabolic Process
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