LDLR 抗体 (AA 22-150)
Quick Overview for LDLR 抗体 (AA 22-150) (ABIN5542334)
抗原
See all LDLR 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 22-150
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原理
- LDLR Antibody
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纯化方法
- Purified antibody
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免疫原
- Purified recombinant fragment of human LDLR (AA: 22-150) expressed in E. Coli.
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亚型
- IgG1
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应用备注
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ELISA: 1/10000
FCM: 1/200 - 1/400
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified antibody in PBS with 0.05 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- LDLR (Low Density Lipoprotein Receptor (LDLR))
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别名
- LDLR
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背景
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The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.r
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分子量
- 95.4 kDa
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基因ID
- 3949
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UniProt
- P01130
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途径
- Hepatitis C, Lipid Metabolism
抗原
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