PPM1F 抗体 (AA 1-454)
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Quick Overview for PPM1F 抗体 (AA 1-454) (ABIN5542151)
抗原
See all PPM1F 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-454
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纯化方法
- Protein-A affinity chromatography
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免疫原
- Recombinant human PPM1F (1-454aa) purified from E. coli
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亚型
- IgG1
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应用备注
- The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended starting dilution is 1:1000.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS, pH 7.4 containing 0.02 % Sodium Azide and 10 % Glycerol
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
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有效期
- 12 months
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- PPM1F (Protein Phosphatase 1F (PP2C Domain Containing) (PPM1F))
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别名
- protein phosphatase 1f,ppm1f
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背景
- PPM1F is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined.
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UniProt
- P49593
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途径
- Positive Regulation of Endopeptidase Activity
抗原
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