MESP1 抗体 (AA 1-268)
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北京 101111
Quick Overview for MESP1 抗体 (AA 1-268) (ABIN5541523)
抗原
See all MESP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-268
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特异性
- This antibody detetcs Human MesP1. Other species not tested.
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纯化方法
- Protein A Chromatography
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免疫原
- Highly pure (> 95%) recombinant Human MesP1 (Met1-Lys268) from produced in insect cells (Cat.-No AR31057PU-N).
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anti-Mesoderm Posterior 1 (MESP1) (AA 1-63) antibody
MESP1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1F9 unconjugated
anti-Mesoderm Posterior 1 (MESP1) (AA 149-268) antibodyMESP1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Mesoderm Posterior 1 (MESP1) (AA 138-173) antibodyMESP1 适用: 小鼠 WB 宿主: 兔 Polyclonal RB52439 unconjugated
anti-Mesoderm Posterior 1 (MESP1) antibodyMESP1 适用: 人 ELISA 宿主: 小鼠 Monoclonal 1A3 unconjugated
anti-Mesoderm Posterior 1 (MESP1) (AA 35-84) antibodyMESP1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Mesoderm Posterior 1 (MESP1) (AA 186-235) antibodyMESP1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Mesoderm Posterior 1 (MESP1) (N-Term) antibodyMESP1 适用: 人, 犬 WB 宿主: 兔 Polyclonal unconjugated
anti-Mesoderm Posterior 1 (MESP1) (AA 46-75), (N-Term) antibodyMESP1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Western blot (1-5 μg/mL). Immunofluorescence. Immunohistochemistry on Frozen Sections (1/200).
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限制
- 仅限研究用
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缓冲液
- 5 mM PBS, pH 7.2 without preservatives or stabilizers
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储存液
- Without preservative
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储存条件
- 4 °C,-20 °C
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储存方法
- Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
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有效期
- 12 months
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- MESP1 (Mesoderm Posterior 1 (MESP1))
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别名
- mesp1
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背景
- ES-cell-based cardiovascular repair requires an in-depth understanding of the molecular mechanisms underlying the differentiation of cardiovascular ES cells. A candidate cardiovascular-fate inducer is the bHLH transcription factor MesP1 (1,2). As one of the earliest markers, it is expressed specifically in almost all cardiovascular precursors and is required for cardiac morphogenesis (2,3). It was shown that MesP1 is a key factor sufficient to induce the formation of ectopic heart tissue in vertebrates and increase cardiovasculogenesis by ES cells. Electrophysiological analysis showed all subtypes of cardiac ES-cell differentiation (4). MesP1 overexpression and knockdown experiments revealed a prominent function of MesP1 in a gene regulatory cascade, causing Dkk-1-mediated blockade of canonical Wnt-signalling. Independent evidence from ChIP and in vitro DNA-binding studies, expression analysis in wild-type and MesP knockout mice, and reporter assays confirm that Dkk-1 is a direct target of MesP1.
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途径
- Regulation of Muscle Cell Differentiation
抗原
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