ESM1 抗体 (AA 19-184)
Quick Overview for ESM1 抗体 (AA 19-184) (ABIN5541433)
抗原
See all ESM1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 19-184
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特异性
- This antibody detects Endocan / ESM1.
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纯化方法
- Protein A chromatography
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免疫原
- Highly pure (> 95%) recombinant human Endocan/ESM1 (Trp19-Arg184) derived from E. coli
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亚型
- IgG
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anti-Endothelial Cell-Specific Molecule 1 (ESM1) (AA 85-184) antibody
ESM1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 6D4 unconjugated
anti-Endothelial Cell-Specific Molecule 1 (ESM1) (AA 51-150) antibodyESM1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Endothelial Cell-Specific Molecule 1 (ESM1) (AA 1-184) antibodyESM1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Endothelial Cell-Specific Molecule 1 (ESM1) (AA 20-184) antibodyESM1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Endothelial Cell-Specific Molecule 1 (ESM1) (AA 22-184) antibodyESM1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Endothelial Cell-Specific Molecule 1 (ESM1) (AA 22-184) antibodyESM1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Endothelial Cell-Specific Molecule 1 (ESM1) (AA 20-184) antibodyESM1 适用: 人 WB 宿主: 小鼠 Monoclonal C7 unconjugated
anti-Endothelial Cell-Specific Molecule 1 (ESM1) (AA 20-184) antibodyESM1 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Endothelial Cell-Specific Molecule 1 (ESM1) (AA 85-184) antibodyESM1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Endothelial Cell-Specific Molecule 1 (ESM1) (AA 1-184) antibodyESM1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Western blot: 1-5 μg/mL. Immunofluorescence : 1/200. Immunhistochemistry on Frozen sections : 1:200.
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限制
- 仅限研究用
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缓冲液
- 5 mM PBS, pH 7.2
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储存条件
- 4 °C,-20 °C
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储存方法
- Prior to reconstitution store at 2-8°C. Following reconstitution store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
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有效期
- 12 months
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- ESM1 (Endothelial Cell-Specific Molecule 1 (ESM1))
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别名
- esm1
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背景
- Endocan, also known as endothelial cell-specific molecule1 (ESM1), is a secreted cysteine-rich dermatan sulfate (DS) proteoglycan primarily expressed by endothelial cells within the vascular capillary network in kidney and in the alveolar walls of the lung. Endocan expression has also been detected in different epithelia and in adipocytes. The expression of endocan is up-regulated by TNFα, IL1β or lipopolysaccharide and down-regulated by IFNγ. The mouse Endocan gene encodes a 184 amino acid (aa) residues precursor protein with a 19 aa hydrophobic signal peptide and a 165 aa mature region with 18 Cysteine residues. The DS chain is covalently attached to serine 137. Endocan has been shown to bind CD11a/CD18 integrin (also known as lymphocyte function-associated antigen1, LFA1) on human lymphocytes, monocytes and Jurkat cells, inhibiting its binding to ICAM1 and reducing LFA1mediated leukocyte activation. Endocan binds via its DS chain to hepatocyte growth factor (HGF) to enhance HGF mitogenic activity. Genetically engineered cells overexpressing Endocan has been shown to induce tumor formation, suggesting that Endocan may be involved in the pathophysiology of tumor growth in vivo. Circulating Endocan can be detected in the serum from healthy subjects.
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途径
- Growth Factor Binding
抗原
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