This antibody recognizes Helios, a transcription factor expressed in some hematopoietic stem cells, and at high levels in thymic-derived regulatory T cells.
纯化方法
Protein-A affinity chromatography
免疫原
Peptide coresponding to the amino acids 51-107 of Helios
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
4 °C
储存方法
Store undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.
有效期
12 months
抗原
IKZF2
(IKAROS Family Zinc Finger 2 (IKZF2))
别名
znfn1a2 (ikzf2, helios)
背景
Helios, also known as IKZF2 (Ikaros family zinc finger protein 2) is a hematopoietic-specific transcription factor involved in the regulation of lymphocyte development, together with other members of this family, such as Aiolos and Ikaros. Helios forms homo- and heterodimers with these proteins and is thought to function predominantly in early hematopoietic development. Expression of Helios, Aiolos and Ikaros is restricted to cells of the hematopoietic system, whereas other family members, Eos and Pegassus, are more widely expressed. Helios is expressed at early stages of thymocyte development. In mature T cells, Helios has been strongly associated with Treg cells.