CBX3 抗体
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北京 101111
Quick Overview for CBX3 抗体 (ABIN5540964)
抗原
See all CBX3 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- This antibody detects HP1γ.
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纯化方法
- Purified
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免疫原
- Recombinant mouse HP1gamma
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亚型
- IgG1
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应用备注
- Immunohistochemistry on paraffin sections: 0.4 μg/mL (1/500). Suggested positive control: Human / Porcine brain cortex.
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限制
- 仅限研究用
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缓冲液
- Buffer System: Phosphate buffered saline pH 7.2 (PBS) Preservatives: 0.01 % Kathon Stabilizers: 5 mg/mL bovine serum albumin (BSA)
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储存条件
- 4 °C,-20 °C
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储存方法
- Store lyophilized at 2-8°C for 6 month or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
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有效期
- 12 months
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- CBX3 (Chromobox Homolog 3 (CBX3))
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别名
- cbx3
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背景
- Heterochromatin Protein 1 (HP1) (Chromobox Homolog, CBX) includes three isoforms in mammals, designated α, β, and γ. HP1 proteins are approximately 25 kDa in size. They are highly conserved adapter proteins with important regulatory functi ons in the cell nucleus. These functions include notably gene silencing by heterochromatin formation. HP1 proteins are fundamental units of heterochromatin packaging that are enriched at the centromeres and telomeres of nearly all Eukaryotic chromosomes. HP1β and γ also localize to euchromatic sites in the genome. Members of the HP1 family are characterized by an N-terminal chromodomain and a C-terminal chromoshadow domain, separated by a Hinge region. Chromodomain and chromoshadow domain establish secondary interactions with a large number of other proteins. HP1 proteins are subject to multiple types of post-translational modifications, including phosphorylation, acetylation, methylation, ubiquitination and sumoylation, suggesting multiple means of regulation.
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UniProt
- P23198
抗原
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