This antibody (clone 29A1.4) recognizes natural killer cell p46 related protein (NKp46) also known as CD335. Staining is not strain specific and the antibody has been used to stain C57BL/6, SJL, CBA/CA and BALB/c Mouse strains. Clone 29A1.4 also activates NK cells in vitro. It does not deplete NK cells in vivo. Species: Mouse.
CD335 is uniquely expressed by resting and activated natural killer (NK) cells, but no expression of CD335 has been detected on B cells, T cells, monocytes or granulocytes. It is a major NK cell lysis receptor for autologous pathogen-infected and tumor target cells during natural cytotoxicity responses. Ligands of CD335 include viral hemagglutinins (HAs) and heparan sulfate proteoglycans (HSPGs) on the surface of tumor cells.