ICAM-3/CD50 抗体
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北京 101111
Quick Overview for ICAM-3/CD50 抗体 (ABIN5540802)
抗原
See all ICAM-3/CD50 (ICAM3) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- This MA4 antibody recognizes a linear epitope in domains 1 and 2 of ICAM-3. MA4 robustly inhibits apoptotic cell interaction with phagocytes.
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纯化方法
- Purified
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免疫原
- Derived by fusion of mouse Ag8.653 cells with spleen cells from a BALB/c mouse immunized with an ICAM-3/HEK transfectant.
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亚型
- IgG1
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应用备注
- ELISA. Western Blot. Immunoprecipitation. Flow Cytometry. Immunocytochemistry. Immunohistochemistry on Frozen Sections. Recommended Dilutions: 1/100-1/200 for Flow Cytometry, and for Immunohistochemistry with avidin-biotinylated horseradish peroxidase complex (ABC) as detection reagent, and 1/100-1/1000 for Immunoblotting applications.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Buffer System: PBS Preservatives: 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
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有效期
- 12 months
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- ICAM-3/CD50 (ICAM3) (Intercellular Adhesion Molecule 3 (ICAM3))
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别名
- cd50,icam3
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背景
- Intercellular adhesion molecule 3 (ICAM3) also known as CD50 (Cluster of Differentiation 50), is a type I transmembrane glycoprotein, which normally contain 2-9 immunoglobulin-like C2-type domains, and binds to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. ICAM-3 has previously been implicated in apoptotic cell clearance, although its precise role in the clearance process is ill defined.
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UniProt
- P32942
抗原
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