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ICT1 抗体 (AA 30-206)

This 小鼠 单克隆 antibody specifically detects ICT1 in WB, FACS 和 EIA. It exhibits reactivity toward 人.
产品编号 ABIN5540729
发货至: 中国
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Quick Overview for ICT1 抗体 (AA 30-206) (ABIN5540729)

抗原

See all ICT1 抗体
ICT1 (Immature Colon Carcinoma Transcript 1 (ICT1))

适用

  • 33
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1

宿主

  • 26
  • 7
小鼠

克隆类型

  • 28
  • 5
单克隆

标记

  • 17
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This ICT1 antibody is un-conjugated

应用范围

  • 30
  • 13
  • 13
  • 9
  • 5
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

克隆位点

AT1E9
  • 抗原表位

    • 15
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 30-206

    特异性

    This antibody detects ICT1 at aa30-206.

    纯化方法

    Protein-A affinity chromatography

    免疫原

    Recombinant human ICT1 (30-206aa) purified from E. coli

    亚型

    IgG1
  • 应用备注

    ELISA. Western blot: Recommended starting dilution is 1:1000. Flow cytometry.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS, pH 7.4 containing 0.02 % Sodium Azide and 10 % Glycerol

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

    有效期

    12 months
  • 抗原

    ICT1 (Immature Colon Carcinoma Transcript 1 (ICT1))

    别名

    ict1,ds1

    背景

    Peptidyl-tRNA hydrolase ICT1 acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. The adult colon epithelium contains 3 differentiated cell types that arise from a multipotent stem cell. Deviation from the normal maturation pathway by neoplastic transformation is thought to initiate in stem cells or their early descendants. This neoplastic-induced deviation is marked by a change in expression of several mRNAs. ICT1 is a member of the prokaryotic/mitochondrial release factor family whose expression is downregulated over 4 fold upon colon stem cell differentiation. This downregulation of ICT1 could lead to its use as a marker for detection of colon carcinomas.

    UniProt

    Q14197
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