GAP43 抗体 (C-Term)
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Quick Overview for GAP43 抗体 (C-Term) (ABIN5540032)
抗原
See all GAP43 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- This antibody detects GAP43.
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纯化方法
- Ig Fraction
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免疫原
- Synthetic peptide corresponding to amino acid residues from the C-terminal region of the rat GAP43 sequence
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应用备注
- Western blot: 1/2000. Immunoflourescence: 1/500.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Buffer System: PBS Preservatives: 10 mM Sodium azide
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储存条件
- 4 °C,-20 °C
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储存方法
- Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
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有效期
- 12 months
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- GAP43 (Growth Associated Protein 43 (GAP43))
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别名
- gap43
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背景
- GAP-43 is thought to have an important role in development and plasticity because it is expressed at high levels in neuronal growth cones during development and during axonal regeneration (Benowitz and Routtenberg, 1997). There is also evidence from knockout animals that GAP-43 serves to amplify pathfinding signals from the growth cone (Strittmatter et al., 1995). GAP-43 is thought to mediate at least some of these effects via interaction with actin. Importantly, phosphorylation at Ser 41 by protein kinase C modulates the interaction of GAP-43 with actin (He et al., 1997) and may also affect neurotransmitter release during forms of plasticity like LTP (Hulo et al., 2002).
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UniProt
- P07936
抗原
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