SET7 抗体 (AA 159-189)
This anti-SET7 antibody is a 兔 多克隆 antibody detecting SET7 in WB 和 IHC (p). Suitable for 人 和 小鼠.
Quick Overview for SET7 抗体 (AA 159-189) (ABIN5539110)
抗原
See all SET7 (SETD8P1) 抗体
SET7 (SETD8P1)
(SET Domain Containing 8 Pseudogene 1 (SETD8P1))
适用
人, 小鼠
宿主
兔
克隆类型
多克隆
标记
This SET7 antibody is un-conjugated
应用范围
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
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抗原表位
- AA 159-189
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This SET7 (SET9) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 159-189 amino acids from the Central region of human SET7 (SET9).
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亚型
- Ig Fraction
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anti-SET Domain Containing 8 Pseudogene 1 (SETD8P1) (AA 289-317), (C-Term) antibody
SETD8P1 适用: 人 WB 宿主: 兔 Polyclonal RB5744 unconjugated
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应用备注
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For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.5 mg/mL
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缓冲液
- Supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- SET7 (SETD8P1) (SET Domain Containing 8 Pseudogene 1 (SETD8P1))
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别名
- SET7
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背景
- Similar to acetylation and phosphorylation, histone methylation at the N-terminal tail has emerged as an important role in regulating chromatin dynamics and gene activity. Histone methylation occurs on arginine and lysine residues and is catalyzed by two families of proteins, the protein arginine methyltransferase family and the SET-domain-containing methyltransferase family. Five members have been identified in the arginine methyltransferase family. About 27 are grouped into the SET-domain family, and another 17 make up the PR domain family that is related to the SET domain family. The retinoblastoma protein-interacting zinc finger geneRIZ1 is a tumor suppressor gene and a FOUNDING member of the PR domain family. RIZ1 inactivation is commonly found in many types of human cancers and occurs through loss of mRNA expression, frame shift mutation, chromosomal deletion, and missense mutation. RIZ1 is also a tumor susceptibility gene in mice. The loss of RIZ1 mRNA in human cancers was shown to associate with DNA methylation of its promoter CpG island. Methylation of the RIZ1 promoter strongly correlated with lost or decreased RIZ1 mRNA expression in breast, liver, colon, and lung cancer cell lines as well as in liver cancer tissues.
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分子量
- 41 kDa
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基因ID
- 80854
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UniProt
- Q8WTS6
抗原
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