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SIGLEC12 抗体 (C-Term)

This anti-SIGLEC12 antibody is a 兔 多克隆 antibody detecting SIGLEC12 in WB 和 IHC (p). Suitable for 人 和 小鼠.
产品编号 ABIN5537532
发货至: 中国

Quick Overview for SIGLEC12 抗体 (C-Term) (ABIN5537532)

抗原

See all SIGLEC12 抗体
SIGLEC12 (Sialic Acid Binding Ig-Like Lectin 12 (SIGLEC12))

适用

  • 33
  • 17
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人, 小鼠

宿主

  • 37
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克隆类型

  • 38
  • 2
多克隆

标记

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This SIGLEC12 antibody is un-conjugated

应用范围

  • 33
  • 18
  • 12
  • 9
  • 6
  • 3
  • 2
  • 1
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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • 抗原表位

    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 565-595, C-Term

    纯化方法

    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

    免疫原

    This SIGLEC12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 565-595 amino acids from the C-terminal region of human SIGLEC12.

    亚型

    Ig Fraction
  • 应用备注

    For WB starting dilution is: 1:1000

    For IHC-P starting dilution is: 1:50~100

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    2 mg/mL

    缓冲液

    Supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • 抗原

    SIGLEC12 (Sialic Acid Binding Ig-Like Lectin 12 (SIGLEC12))

    别名

    SIGLEC12

    背景

    Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. SIGLEC12 is a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. This protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor.

    分子量

    65 kDa

    基因ID

    89858

    UniProt

    Q96PQ1
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