KDM5B 抗体 (N-Term)
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北京 101111
Quick Overview for KDM5B 抗体 (N-Term) (ABIN5537034)
抗原
See all KDM5B 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 192-224, N-Term
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This JARID1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 192-224 amino acids from the N-terminal region of human JARID1B.
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亚型
- Ig Fraction
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应用备注
- For WB starting dilution is: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.5 mg/mL
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缓冲液
- Supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- KDM5B (Lysine (K)-Specific Demethylase 5B (KDM5B))
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别名
- JARID1B
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背景
- Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.
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分子量
- 176 kDa
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基因ID
- 10765
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UniProt
- Q9UGL1
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途径
- Warburg Effect
抗原
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