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LIN28B 抗体 (AA 95-128)

This anti-LIN28B antibody is a 兔 多克隆 antibody detecting LIN28B in WB, FACS, IF 和 IHC (p). Suitable for 人.
产品编号 ABIN5536364
发货至: 中国

Quick Overview for LIN28B 抗体 (AA 95-128) (ABIN5536364)

抗原

See all LIN28B 抗体
LIN28B (Lin-28 Homolog B (LIN28B))

适用

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宿主

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克隆类型

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多克隆

标记

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This LIN28B antibody is un-conjugated

应用范围

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Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • 抗原表位

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    AA 95-128

    纯化方法

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    免疫原

    This LIN28B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 95-128 amino acids from the Central region of human LIN28B.

    亚型

    Ig Fraction
  • 应用备注

    For IHC-P starting dilution is: 1:25

    For WB starting dilution is: 1:1000

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.33 mg/mL

    缓冲液

    Supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • 抗原

    LIN28B (Lin-28 Homolog B (LIN28B))

    别名

    LIN28B

    背景

    Lin-28 homolog B (LIN28B) is overexpressed in hepatocellular carcinoma. The heterochronic gene lin-28 is a key regulator of developmental timing in the nematode Caenorhabditis elegans. Similar with lin-28 proteins, LIN28B conserves a cold shock domain and a pair of CCHC zinc finger domains. Phylogenetic analysis suggests that they might arise as a result of duplication from an ancestral gene. Overexpression of LIN28B was noted in most HCC cell lines and clinical samples. A short LIN28B isoform was also identified in non-tumor liver tissue and fetal liver. Although predominantly localized in the cytoplasm, LIN28B protein shows cell cycle-dependent nuclear translocation in Huh7 cells. Induced expression of exogenous LIN28B in a tet-off cell line promoted cancer cell proliferation.

    分子量

    27 kDa

    基因ID

    389421

    UniProt

    Q6ZN17
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