GOPC 抗体
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北京 101111
Quick Overview for GOPC 抗体 (ABIN5536182)
抗原
See all GOPC 抗体适用
宿主
克隆类型
标记
应用范围
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This CALR Antibody is generated from rabbits immunized with a recombinant protein of human CALR.
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亚型
- Ig Fraction
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anti-Golgi-Associated PDZ and Coiled-Coil Motif Containing (GOPC) (AA 203-462) antibody
GOPC 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Golgi-Associated PDZ and Coiled-Coil Motif Containing (GOPC) antibodyGOPC 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Golgi-Associated PDZ and Coiled-Coil Motif Containing (GOPC) (AA 361-390), (C-Term) antibodyGOPC 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB13073 unconjugated
anti-Golgi-Associated PDZ and Coiled-Coil Motif Containing (GOPC) (AA 195-454) antibodyGOPC 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Golgi-Associated PDZ and Coiled-Coil Motif Containing (GOPC) (C-Term) antibodyVerified GOPC 适用: 人 WB, ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-Golgi-Associated PDZ and Coiled-Coil Motif Containing (GOPC) antibodyKD Validated GOPC 适用: 人 WB, ICC, FACS 宿主: 兔 Monoclonal 23GB5870 unconjugated Recombinant Antibody
anti-Golgi-Associated PDZ and Coiled-Coil Motif Containing (GOPC) (AA 35-84) antibodyGOPC 适用: 人, 小鼠, 大鼠, Cow, 犬, 兔, 豚鼠, 斑马鱼, 猴, Pig, 小鸡, Bat, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Golgi-Associated PDZ and Coiled-Coil Motif Containing (GOPC) (AA 251-300) antibodyGOPC 适用: 人, 小鼠, 大鼠, Cow, 兔, 豚鼠, 马, 猴, Pig, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Golgi-Associated PDZ and Coiled-Coil Motif Containing (GOPC) (C-Term) antibodyGOPC 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Golgi-Associated PDZ and Coiled-Coil Motif Containing (GOPC) (N-Term) antibodyGOPC 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For FACS starting dilution is: 1:10~50 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.5 mg/mL
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缓冲液
- Supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- GOPC (Golgi-Associated PDZ and Coiled-Coil Motif Containing (GOPC))
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别名
- CAL
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背景
- Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes.
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分子量
- 48 kDa
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基因ID
- 811
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UniProt
- P27797
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途径
- Maintenance of Protein Location, Asymmetric Protein Localization
抗原
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