P-Glycoprotein 抗体 (AA 647-677)
Our Local Distributor
北京 101111
Quick Overview for P-Glycoprotein 抗体 (AA 647-677) (ABIN5535640)
抗原
适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 647-677
-
纯化方法
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
-
免疫原
- This P-Glycoprotein (ABCB1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 647-677 amino acids from the Central region of human P-Glycoprotein (ABCB1).
-
亚型
- Ig Fraction
-
-
anti-P-Glycoprotein antibody
适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-P-Glycoprotein antibody适用: 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-P-Glycoprotein (AA 647-677) antibody适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-P-Glycoprotein antibody适用: 人, Hamster WB, IHC, FACS, ICC 宿主: 小鼠 Monoclonal JSB-1 unconjugated
anti-P-Glycoprotein antibody适用: 人, Hamster WB, IHC, FACS 宿主: 小鼠 Monoclonal JSB-1 unconjugated
-
-
应用备注
- For WB starting dilution is: 1:1000
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 2 mg/mL
-
缓冲液
- Supplied in PBS with 0.09 % (W/V) sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
-
-
- P-Glycoprotein
-
背景
- The membrane-associated ABCB1 protein is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. ABCB1 is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
-
分子量
- 141 kDa
-
基因ID
- 5243
-
UniProt
- P08183
抗原
-
